Recent Publications
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- 1. Hagiwara, T., Minami, R., Ushio, C., Yokota, N., and Kawahara, H. (2023) Proteotoxic stresses stimulates dissociation of UBL4A from the tail-anchored protein recognition complex.
- Biochem. J. (London), doi: 10.1042/BCJ20230267
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- 2. Takahashi, T., Shirai, J., Matsuda, M., Nakanaga, S., Matsushita, S., Wakita, K., Hayashishita, M., Suzuki, R., Noguchi, A., Yokota, N., and Kawahara, H. (2023) Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family
- GTPases.
- iScience, 26: doi.org/10.1016/j.isci.2023.106652
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- 3. Miyauchi, M., Matsumura, R., and Kawahara, H. (2023) BAG6 supports stress fiber formation by preventing the ubiquitin-mediated degradation of RhoA.
- Mol. Biol. Cell. 34: doi: 10.1091/mbc.E22-08-0355.
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- 4. Matsuura, Y., Noguchi, A., Yokota, N., and Kawahara, H. (2020) Nuclear accumulation of ZFP36L1 is cell cycle-dependent and determined by a C-terminal serine-rich cluster.
- J. Biochem. 168, 477-489.
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- 5. Mimami, S., Yokota, N., and Kawahara, H. (2020) BAG6 contributes glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
- Biol. Open. 9, bio047324.
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- 6. Takahashi, T., Minami, S., Tajima, K., Tsuchiya, Y., Sakai, N., Suga, K., Hisanaga, S., Obayashi, N., Fukuda, M., and Kawahara, H. (2019) Cytoplasmic control of Rab-family small GTPases through BAG6.
- EMBO Rep. 20: e46794.
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- 7. Kamikubo, K., Kato, H., Kioka, H., Yamazaki, S., Tsukamoto, O., Nishida, Y., Asano, Y., Imamura, H., Kawahara, H., Shintani, Y., and Takashima, S. (2019) A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2.
- J. Biol. Chem. 294, 14562-14573.
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- 8. Hayashishita, M., Kawahara, H., and Yokota N. (2019) BAG6 deficiency induces mis-distribution of mitochondrial clusters under depolarization.
- FEBS Open Bio. 9, 1281-1291.(本研究室の大学院生による論文)
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- 9. Demizu, S., Asaka, M., Kawahara, H. and Sasaki, E. (2019) TAS-203, an oral phosphodiesterase 4 inhibitor, suppresses goblet cell hyperplasia and MUC5AC production in rodent models.
- Eur. J. Pharmacol. 849, 22-29.(本研究室の大学院生による論文)
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- 10. Noguchi, A., Adachi, S., Yokota, N., Hatta, T., Natsume, T., and Kawahara, H. (2018) ZFP36L2 is a cell cycle-regulated CCCH-protein necessary for DNA lesion-induced S-phase arrest.
- Biol. Open 7, bio031575.
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- 11. Kondo, M., Noguchi, A., Matsuura, Y., Shimada, M., Yokota, N., and Kawahara, H. (2018) Novel phosphorelay-dependent control of ZFP36L1 protein during the cell cycle.
- Biochem. Biophys. Res. Comm. 501; 387-393.
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- 12. Xuan, X., Matsumoto, S., Endo, S., Fukushima, A., Kawahara, H., Saeki, Y., and Komada, M. (2018) Deubiquitinases USP5 and USP13 are recruited to and regulate heat-induced stress granules by deubiquitinating activities.
- J. Cell Sci. 131, 1-11. doi: 10.1242/jcs.210856.
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- 13. Yamamoto, K., Hayashishita, M., Minami, S., Suzuki, K., Hagiwara, T., Noguchi, A., and Kawahara, H. (2017) Elimination of a signal-sequence uncleaved form of defective HLA protein through BAG6.
- Sci. Rep. 7, DOI:10.1038/s41598-017-14975-9
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- 14. Suzuki, R. and Kawahara, H. (2016) UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.
- EMBO Rep. 17, 842–857.(本研究室の大学院生による論文)
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- 15. Tanaka, H., Takahashi, T., Xie, Y., Minami, R., Yanagi, Y., Hayashishita, M., Suzuki, R., Yokota, N., Shimada, M., Mizushima, T., Kuwabara, N., Kato, R., and Kawahara, H. (2016) A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
- FEBS J. 283, 662–677.
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- 16. Takasugi, T., Saito, T., Asada, A., Kawahara, H. and Hisanaga, S.-I. (2016) Two degradation pathways of the p35 Cdk5 activation subunit, dependent and independent of ubiquitination.
- J. Biol. Chem. 291, 4649-4657. doi: 10.1074/jbc.M115.692871
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- 17. Yamaki, Y., Kagawa, H., Hatta, T., Natsume, T., and Kawahara, H. (2016) The C-terminal cytoplasmic tail of hedgehog receptor Patched1 is a platform for E3 ubiquitin ligase complexes.
- Mol. Cell. Biochem. 414: 1-12.
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- 18. Kuwabara, N., Minami, R., Yokota, N., Matsumoto, H., Senda, T., Kawahara, H. (co-corresponding author), and Kato, R. (2015) Structure of a BAG6 (Bcl-2-associated athanogene 6)-Ubl4a (ubiquitin-like protein 4a) complex reveals a novel binding interface that functions in tail-anchored protein biogenesis.
- J. Biol. Chem. 290, 9387-9398.
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- 19. Kawahara, H., Minami, R. and Yokota, N. (2013)
- JB Review: BAG6/BAT3: Emerging roles in quality control for nascent polypeptides.
- J. Biochem. 153, 147-160.
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- 20. Kagawa, H., Shino, Y., Kobayashi, D., Demizu, S., Shimada. M., Ariga, H. and Kawahara, H. (2011) A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1.
- PLoS ONE 6: e18638.
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- 21. Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T.C., and Hisanaga, S. (2011) Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.
- J. Neurochem. 117:504-515.
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- 22. Minami, R., Hayakawa, A., Kagawa, H., Yanagi, Y., Yokosawa, H. and Kawahara, H. (2010) BAG-6 is essential for selective elimination of defective proteasomal substrates.
- J. Cell Biol. 190: 637-650.
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- 23. Ojima, K., Y Kawabata, Y., Nakao, H., Nakao, K., Doi, N., Kitamura, F., Ono, Y., Hata, S., Suzuki, H., Kawahara, H., Labeit, S., Toyama-Sorimachi, N., Suzuki, K., Maeda, T., Abe, K., Aiba, A., and Sorimachi, H. (2010) Role of dynamic distribution of muscle-specific calpain in physical-stress adaptation and muscular dystrophy in mice.
- J. Clin. Invest. 120: 2672–2683.
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- 24. Shimada, M., Kanematsu, K., Tanaka, K., Yokosawa, H. and Kawahara, H. (2006) Proteasomal ubiquitin receptor RPN-10 controls sex determination in Caenorhabditis elegans.
- Mol. Biol. Cell 17: 5356-5371.
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