最近の研究業績
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- Taeko Kimura, Tomohisa Hosokawa,, Masato Taoka, Koji Tsutsumi, Kanae Ando, Koichi Ishiguro, Masato Hosokawa, Masato Hasegawa, and Shin-ichi Hisanaga. Quantitative and combinatory determination of in situ phosphorylation of tau and its FTDP-17 mutants. Scientific Reports, ep 19;6:33479. doi: 10.1038/srep33479.
- Govinda Sharma, Koji Tsutsumi , Taro Saito , Akiko Asada , Kanae Ando , Mineko
- Tomomura, and Shin-ichi Hisanaga. The kinase activity of endosomal kinase LMTK1A regulates its cellular localization and interactions with cytoskeletons. Genes to Cells, 2016 Oct;21(10):1080-1094. doi: 10.1111/gtc.12404.
- Kanae Ando, Mikiko Oka, Yosuke Ohtake, Motoki Hayashishita, Sawako Shimizu, Shin-ichi Hisanaga, Koichi M. Iijima, (2016) Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated. Biochemical and Biophysical Research Communications, Volume 478, Issue 2, Pages 929–934
- Ando, K.*, Maruko-Otake, A., Ohtake, Y., Hayashishita, M., Sekiya, M., and Iijima, K. M. (2016) Stabilization of microtubule-unbound tau via tau phosphorylation at Ser262/356 by Par-1/MARK contributes to augmentation of AD-related phosphorylation and Aβ42-induced tau toxicity. PLoS Genetics (12(3): e1005917. doi:10.1371/journal. pgen.1005917)
- Fuchigami, T., Sato, Y., Tomita, Y., Takano, T., Miyauchi, S., Tsuchiya, Y., Saito, T., Kubo, K., Nakajima, K., Fukuda, M., Hattori, M. and Hisanaga, S. Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin-receptors, ApoER2 and VLDLR, in neurons. Genes to Cells, in press.
- Kimura, T., Tsutsumi, K., Taoka, M., Saito, T., Masuda-Suzukake, M., Ishiguro, K., Plattner, F., Uchida, T., Isobe, T., Hasegawa, M., and Hisanaga, S. Pin1 Stimulates Dephosphorylation of Tau at Cdk5-Dependent Alzheimer Phosphorylation Sites. J. Biol. Chem. In press/
- 斎藤太郎、久永眞市. 神経細胞におけるCDK5の機能とその異常活性化による神経変性疾患. 細胞周期2013.実験医学 (羊土社)、31, 265-270, 2013.
- Hisanaga S., Asada A. Cdk5-induced neuronal cell death: the activation of the conventional Rb-E2F G1 pathway in post-mitotic neurons. Cell Cycle News & Views, 11, 2049, 2012.
- Takano, T., Tomomura, M., Yoshioka, N., Tsutsumi, K., Terasawa, Y., Saito, T., Kawano, H., Kamiguchi, H., Fukuda, M., Hisanaga, S. LMTK1/AATYK1 is a bovel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner. J. Neurosci. 32, 6587– 6599, 2012
- Asada, A., Saito, T., and Hisanaga, S. Subcellular localization of active Cdk5 is determined by its own kinase activity. J. Cell Sci., 125, 3421-3429, 2012.
- Shahpasand, S., Uemura, I., Saito, T., Asano, T., Hata, K., Shibata, K., Toyoshima, Y., Hasegawa, M., and Hisanaga, S. Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer’s disease. J. Neurosci., 32, 2430-2441, 2012.
- Sato, K., Minegishi, S., Takano, J., Plattner, F., Saito, T., Asada, A., Kawahara, H., Iwata, N., Saido, T. C., Hisanaga, S. Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25. J. Neurochem. 117, 504-515, 2011.
- Minegishi, S., Asada, A., Miyauchi, S., Fuchigami, T., Saito, T., and Hisanaga, S.
- Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39. Biochemistry, 49, 5482-5493, 2010
- Takano, T., Tsutsumi, K., Saito, T., Asada, A., Tomomura, M., Fukuda, M., Hisanaga, S. AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway. Genes Cells 15, 783-797, 2010.
- Hosokawa, T., Saito, T., Asada, A., Fukunaga, K., and Hisanaga, S. Quantitative Measurement of In Vivo Phosphorylation States of Cdk5 Activator p35 by Phos-tag SDS-PAGE. Mol. Cell. Proteomics. 9, 1133-1143, 2010.
- Asada, A, Takahashi, J., Taniguchi, M., Yamamoto, H., Kimura, T., Saito, T., and Hisanaga, S. Neuronal expression of two isoforms of mouse Septin 5. J. Neurosci. Res. 88,1309-1316, 2010.
- Endo, R., Saito, T., Asada, A., Kawahara, H., Ohshima, T. and Hisanaga, S. Commitment of MPP+-induced neuronal cell death by proteasome-mediated degradation of p35 Cdk5 activator. J. Biol. Chem., 284, 26029-26039, 2009.
- Yotsumoto, K., Saito, T., Asada, A., Oikawa, T., Kimura, T., Uchida, C., Ishiguro, K., Uchida, T., Hasegawa, M., & Hisanaga, S. Effect of pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant tau. J. Biol. Chem. 284, 16840-16847, 2009.
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