最近の研究業績
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- Watanabe, K. and *Sakai, T. (2015) Knockout mutations of insulin-like peptides enhance sexual receptivity in Drosophila virgin females. Genes and Genetic System (in press)
- Ohashi, H. and *Sakai, T. (2015) Novel behavioral assay of wasabi avoidance in Drosophila using a video tracking system. Appl. Entmol. Zool. 50: 137-142.
- Sato, S., Kitamoto, T. and *Sakai, T. (2014) Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications. Front. Behav. Neurosci. 8: Article 400 (doi: 10.3389/fnbeh.2014.00400)
- *Sakai, T., Watanabe, K., Ohashi, H., Sato, S., Inami, S., Shimada, N., Kitamoto, T. (2014) Insulin-producing cells regulate the sexual receptivity through the Painless TRP channel in Drosophila virgin females. PLoS ONE 9(2): e88175
- Amano A, Tsunoda M, Aigaki T, Maruyama N, Ishigami A. (2013) Effect of ascorbic acid deficiency on catecholamine synthesis in adrenal glands of SMP30/GNL knockout mice. Eur J Nutr. In Press.
- Trindade LS, Aigaki T, Peixoto AA, Balduino A, Mânica da Cruz IB, Heddle JG. (2013) A novel classification system for evolutionary aging theories. Front Genet. 4:25.
- Cheng Z, Tsuda M, Kishita Y, Sato Y, Aigaki T. (2013) Impaired energy metabolism in a Drosophila model of mitochondrial aconitase deficiency. Biochem Biophys Res Commun. 433, 145-150.
- Aizawa S, Senda M, Harada A, Maruyama N, Ishida T, Aigaki T, Ishigami A, Senda T. (2013) Structural basis of the γ-lactone-ring formation in ascorbic acid biosynthesis by the senescence marker protein-30/gluconolactonase. PLoS One. 8, e53706.
- Kadengodlu PA, Aigaki T, Abe H, Ito Y. (2013) Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle. Mol Biosyst. 9, 965-968.
- Sakai, T., Sato, S., Ishimoto, H., *Kitamoto, T. (2013) Significance of the centrally expressed TRP channel Painless in Drosophila courtship memory. Learning & Memory 20: 34-40.
- Asano T., Taoka M., Shinkawa T., Yamauchi Y., Isobe T., Sato D.(2013)Identification of a cuticle protein with unique repeated motifs in the silkworm, Bombyx mori. Insect Biochem. Molec. Biol. 43, 344-351.
- 八木勇三,佐藤由紀子,村松由記子,原高明,相垣敏郎 (2013) ショウジョウバエの寿命に対する赤ワイン由来ポリフェノールProtocatechuic acid の効果. Food function (in press).
- *Sakai, T., Inami, S., Sato, S., Kitamoto, T. (2012) Fan-shaped body neurons are involved in period-dependent regulation of long-term courtship memory in Drosophila. Learning & Memory 19: 571-574.
- Tomioka S, Aigaki T, Matsuo T. (2012) Conserved cis-regulatory elements of two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. Genes Genet Syst. 87, 323-329.
- Kadengodlu PA, Hebishima T, Takeshima SN, Ito M, Liu M, Abe H, Aida Y, Aigaki T, Ito Y. (2012) Positively charged cholesterol-recombinant human gelatins foster the cellular uptake of proteins and murine immune reactions. J Nanomedicine 7, 5437-5450.
- Amano A, Tsunoda M, Aigaki T, Maruyama N, Ishigami A. (2012) Age-related changes of dopamine, noradrenaline and adrenaline in adrenal glands of mice. Geriatr Gerontol. 13, 490-496.
- Nakagawa-Yagi Y, Sato Y, Matsumoto E, Nakatsuka SI, Sakaki T, Muramatsu Y, Hara T, Aigaki T. (2012) Pharmacological modulation of histone demethylase activity by a small molecule isolated from subcritical water extracts of Sasa senanensis leaves prolongs the lifespan of Drosophila melanogaster. BMC Complement Altern Med. 12,101.
- Trindade LS, Balduino A, Aigaki T, Heddle JG. (2012) Senemorphism: a novel perspective on aging patterns and its implication for diet-related biology. Biogerontology. 13,457-466.
- Takeo S, Swanson SK, Nandanan K, Nakai Y, Aigaki T, Washburn MP, Florens L, Hawley RS. (2012) Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc Natl Acad Sci U S A. 109, 6382-6389.
- Kishita Y, Tsuda M, Aigaki T. (2012) Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency. Biochem Biophys Res Commun. 419, 344-349.
- Harada E, Nakagawa J, Asano T, Taoka M, Sorimachi H, Ito Y, Aigaki T, Matsuo T. (2012) Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. PLoS One. 7, e29710.
- Takeo S, Swanson SK, Nandanan K, Nakai Y, Aigaki T, Washburn MP, Florens L, Hawley RS. (2012) Shaggy/glycogen synthase kinase 3β and phosphorylation of Sarah/regulator of calcineurin are essential for completion of Drosophila female meiosis. Proc Natl Acad Sci U S A, 109, 6382-6389.
- Kishita Y, Tsuda M, Aigaki T. (2012) Impaired fatty acid oxidation in a Drosophila model of mitochondrial trifunctional protein (MTP) deficiency. Biochem Biophys Res Commun. 419, 344-349.
- Harada E, Nakagawa J, Asano T, Taoka M, Sorimachi H, Ito Y, Aigaki T, Matsuo T. (2012) Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. PLoS One, 7, e29710.
- Kourosh Shahpasand, Isao Uemura, Taro Saito, Tsunaki Asano, Kenji Hata, Keitaro Shibata, Yoko Toyoshima, Masato Hasegawa and Shin-ichi Hisanaga,(2012)Regulation of mitochondrial transport and inter-microtubule spacing by Tau phosphorylation at the sites hyperphosphorylated in Alzheimer’s disease, J. Neuroscience, 32, 2430-2441.
- Tomita J, Mitsuyoshi M, Ueno T, Aso Y, Tanimoto H, Nakai Y, Aigaki T, Kume S, Kume K. (2011) Pan-neuronal knockdown of calcineurin reduces sleep in the fruit fly, Drosophila melanogaster. J Neurosci. 31, 13137-13146.
- Amano A, Handa S, Aigaki T, Shigemoto K, Maruyama N, Ishigami A. (2011) Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport. J Biochem. 150, 671-678.
- Nakai Y, Horiuchi J, Tsuda M, Takeo S, Akahori S, Matsuo T, Kume K, Aigaki T. (2011) Calcineurin and its regulator sra/DSCR1 are essential for sleep in Drosophila. J Neurosci, 3012759-12766.
- Wang W, Hara S, Liu M, Aigaki T, Shimizu S, Ito Y. (2011) Polypeptide aptamer selection using a stabilized ribosome display. J Biosci Bioeng, 112, 515-517.
- Rotkopf S, Hamberg Y, Aigaki T, Snapper SB, Shilo BZ, Schejter ED. (2011) The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. Development, 188, 105-125.
- 坂井貴臣(2011)「ショウジョウバエメスの性行動の神経遺伝学的研究」 比較生理生化学 28: 225-230.
- Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE. (2011) Identification of Novel Ras-cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-family/JNK Pathway is a Central Driver of Tumorigenesis. Genetics, 188, 105-125.
- Funakoshi M, Tsuda M, Muramatsu K, Hatsuda H, Morishita S, Aigaki T. (2011) A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila. Biochem Biophys Res Commun. 405, 667-72.
- Sakai T and Aigaki T. (2010) The Drosophila calcineurin regulator, Sarah, is involved in male courtship. NeuroReport 21: 985-988.
- Sakai T and Aigaki T. (2010) Overexpression of a repressor isoform of CrebB-17A lengthens courtship break in the fruit fly Drosophila melanogaster (Diptera: Drosophilidae). Applied Entomology and Zoology 45: 533-539.
- Tsuda M, Kawaida R, Kobayashi K, Shinagawa A, Sawada T, Yamada R, Yamamoto K, Aigaki T. (2010) POSH promotes cell survival in Drosophila and in human RASF cells. FEBS Lett, 584, 4689-4694.
- Ueyama M, Akimoto Y, Ichimiya T, Ueda R, Kawakami H, Aigaki T, Nishihara S. (2010) Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome. PLoS One, 5, e11557.
- Yasukawa J, Tomioka S, Aigaki T, Matsuo T. (2010) Evolution of expression patterns of two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila. Gene, 467, 25-34.
- Yamazaki D, Horiuchi J, Miyashita T, Saitoe M. (2010) Acute inhibition of PKA activity at old ages ameliorates age-related memory impairment in Drosophila. J Neurosci, 30, 15573-15577.
- Tsuda M, Ootaka R, Ohkura C, Kishita Y, Seong KH, Matsuo T, Aigaki T. (2010) Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. FEBS Lett, 584, 3398-401.
- Takeo S, Hawley RS, Aigaki T. (2010) Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Dev Biol, 344, 957-67.
- Tsuda M, Kobayashi T, Matsuo T, Aigaki T. (2010) Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Abeta-induced neurotoxicity in Drosophila. FEBS Lett, 584, 2916-20.
- Amano A, Aigaki T, Maruyama N, Ishigami A. (2010) Ascorbic acid depletion enhances expression of the sodium-dependent vitamin C transporters, SVCT1 and SVCT2, and uptake of ascorbic acid in livers of SMP30/GNL knockout mice. Arch Biochem Biophys. 496, 38–44.
- Ahsan, B., Saito, TL., Hashimoto, S., Muramatsu, K., Tsuda, M., Sasaki, A., Matsushima, K., Aigaki, T. and Morishita, S. (2009) MachiBase: a Drosophila melanogaster 5'-end mRNA transcription database. Nucleic Acids Res. 37, D49-53.
- Tsubouchi, A., Tsuyama, T., Fujioka, M., Kohda, H., Okamoto-Furuta, K., Aigaki, T. and Uemura, T. (2009) Mitochondrial Protein Preli-like Is Required for Development of Dendritic Arbors and Prevents Their Regression in the Drosophila Sensory Nervous System. Development, 136, 3757-3766.
- Sakai T, Kasuya J, Kitamoto T and Aigaki T. (2009) The Drosophila TRPA channel, Painless, regulates sexual receptivity in virgin females. Genes, Brain and Behavior 8: 546-557.
- Ishimoto H,Sakai T, and Kitamoto T. (2009) Ecdysone signaling regulates courtship long-term memory formation in adult Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 106: 6381-6386.
- Matsuo, T. (2008) Rapid evolution of two odorant-binding protein genes, Obp57d and Obp57e, in the Drosophila melanogaster species group. Genetics 178:1061-1072.
- Harada, E., Haba, D., Aigaki, T., Matsuo, T. (2008) Behavioral analyses of mutants for two odorant-binding protein genes, Obp57d and Obp57e, in Drosophila melanogaster. Genes Genet. Syst. 83:257-264.
- Matsuo, T. (2008) Genes for host-plant selection in Drosophila. J. Neurogenetics 22:195-210
- 松尾隆嗣 (2008) ショウジョウバエの食性の進化 細胞工学 27:1112-1117
- Matsuno M, Horiuchi J, Tully T, Saitoe M. (2008) The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Proc Natl Acad Sci USA. 106, 310-315.
- Horiuchi, J., Yamazaki, D., Naganos, S., Aigaki, T. and Saitoe, M. (2008) Protein kinase A inhibits a consolidated form of memory in Drosophila. Proc Natl Acad Sci USA. 105, 20976-20981.
- List, O., Togawa, T., Tsuda, M., Matsuo, T., Elard, L. and Aigaki, T. (2009) Overexpression of grappa encoding a histone methyltransferase enhances stress resistance in Drosophila. Hereditas, 146, 19-28.
- Suzuki, E., Zhao Y., Ito, S., Sawatsubashi, S., Murata, T., Furutani, T., Shirode, Y., Yamagata, K., Tanabe, M., Kimura, S., Ueda, T., Fujiyama, S., Lim, J., Matsukawa, H., Kouzmenko, AP., Aigaki, T., Tabata, T., Takeyama, KI, and Kato, S. (2009) Aberrant E2F activation by polyglutamine expansion of androgen receptor in SBMA neurotoxicity. Proc Natl Acad Sci USA.106, 3818-3822.
- Ahsan, B., Saito, TL., Hashimoto, S., Muramatsu, K., Tsuda, M., Sasaki, A., Matsushima, K., Aigaki, T. and Morishita, S. (2009) MachiBase: a Drosophila melanogaster 5'-end mRNA transcription database. Nucleic Acids Res. 37, D49-53.
- Shindo, M., Wada, H., Kaido, M., Tateno, M., Aigaki, T., Tsuda, L. and Hayashi, S. (2008) Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis. Development 135, 1355-1364
- 木下善仁,津田学,相垣敏郎 (2008) TCA回路を中心とした代謝調節と寿命制御,基礎老化研究 32, 21-23.
- Kaji, K., Tomino, S., and Asano, T. (2009) A serine protease in the midgut of the silkworm, Bombyx mori: Protein sequencing, identification of cDNA, demonstration of its synthesis as zymogen form and activation during midgut remodeling. Insect Biochem and Mol biol. 39. 207-17.
- Asano, T. and Takebuchi, K. (2009) Identification of the gene encoding pro-phenoloxidase A3 in the fruitfly, Drosophila melanogaster. Insect Mol Biol. 18, 223-232
- Nam, H-J. Jang, I-H., Asano, T. and Lee, W-J. (2008) Involvement of pro-phenoloxidase 3 in lamellocyte-meidated spontaneous melanization in Drosophila. Molecular and Cells. 2008. 2, .606-610
- Yao, Y., Wu, Y., Yin, C., Ozawa, R., Aigaki, T., Wouda, R.R., Noordermeer, J.N., Fradkin, L.G., Hing, H. (2007) Antagonistic roles of Wnt5 and the Drl receptor in patterning the Drosophila antennal lobe. Nat Neurosci. 10, 1423-1432
- Taniguchi K, Hozumi S, Maeda R, Ooike M, Sasamura T, Aigaki T, Matsuno K. (2007) D-JNK signaling in visceral muscle cells controls the laterality of the Drosophila gut. Dev Biol. 311, 251-263
- Tsuda M, Sugiura T, Ishii T, Ishii N, Aigaki T. (2007) A mev-1-like dominant-negative SdhC increases oxidative stress and reduces lifespan in Drosophila. Biochem Biophys Res Commun. 363, 342-346.
- Sakurai T, K., Kojima, T., Aigaki, T., *Hayashi, S (2007) Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation, Dev Biol, 309, 126-136
- Matsuo, T., Sugaya, S., Yasukawa, J., Aigaki, T., Fuyama, Y. (2007) Odorant-Binding Proteins OBP57d and OBP57e Affect Taste Perception and Host-Plant Preference in Drosophila sechellia. PLoS Biology. 5(5):e118
- Umeda-Kameyama, Y., Tsuda, M., Ohkura, C., Matsuo, T., Namba, Y., Ohuchi, Y. and Aigaki, T. (2007) Thioredoxin suppresses Pael-R-induced neurotoxicity and extends longevity in Drosophila. J. Biol. Chem. 282, 11180-11187.
- Shima, S., Aigaki, T., Nojima, T. and Yamamoto, D. (2007) Identification of trf2 mutants of Drosophila with defects in anterior spiracle eversion. Arch. Insect Biochem. Physiol. 64, 157-163.
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